The Biology of Scarless Fetal Wound Repair

Background Data Fetal skin wound healing is characterized by the absence of scar tissue formation. This unique repair process is not dependent on the sterile, aqueous intrauterine environment. The differences between fetal and adult skin wound healing appear to reflect processes intrinsic to fetal tissue, such as the unique fetal fibroblasts, a more rapid and ordered deposition and turnover of tissue components, and, particularly, a markedly reduced inflammatory infiltrate and cytokine profile. Scarless fetal wounds are relatively deficient in the inflammatory cytokine, transforming growth factor ,B (TGF-f). In contrast, the fibrosis characteristic of adult wound repair may be associated with TGF-,B excess. Recent experimental studies suggest that specific anti-TGF-fl therapeutic strategies can ameliorate scar formation in adult wound repair and fibrotic diseases. Inhibitors of TGF-,B may be important future drugs to control scar.